Optimization and novel applications of the in vitro pyrogen test (IPT) using human whole blood
نویسندگان
چکیده
Development, validation and applications of the in vitro pyrogen test (IPT) based on human whole blood (submitted to J Clin Immunol) International validation of novel pyrogen tests based on human monocytoid cells. on cryopreserved human whole blood for lipidic parenterals (Pharmeuropa, in print) on cryopreserved human primary blood cells (J Immunol Methods, in print) Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli. pyrogen tests based on the human fever reaction. I thank all members of the " Lehrstuhl Wendel " for their support, their contribution to the outstanding working atmosphere and for five wonderful years. And last but not least I thank my parents Klaus and Birgit Schindler.
منابع مشابه
Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli.
A comparison between humans and rabbits was performed based on stimulation of whole blood with well-known pyrogens from Gram-negative and Gram-positive bacteria, such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), respectively. The reactivity was measured as release of IL-1 beta and IL-8 by ELISA. The reactivity of the two species towards LPS was found to be similar, whereas their rea...
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